PRF – fibrin-rich plasma – the latest natural tissue regenerative and rejuvenating treatment with plasma serum, suitable for lack of volume, skin depression, dents in the eye area and wrinkles on the forehead. Fibrin is a biological scaffold that forms when an injury occurs anywhere in the body. Platelets normally circulate in the blood and bind to the fibrin scaffold. Thus connected, they are activated and release growth factors, which are small “granules”. These growth factors begin the process of wound healing by creating new skin cells, collagen and blood vessels.