Dermal fillers with hyaluronic acid

Dermal fillers with hyaluronic acid are one of the main means of compensating for the manifestations of age. Ageing is a process that causes anatomical and cellular changes, which are expressed in the formation of superficial and deep wrinkles, a reduction in the volume of the cheekbones and lips, a reconfiguration of the shape and relaxation of the facial contour, a lack of elasticity and “fading” of the skin.

These changes are due to the loss of subcutaneous adipose tissue, reduced synthesis of collagen, elastin and hyaluronic acid. Hyaluronic acid is one of the most abundant polysaccharides synthesized by the body, a major structural component of connective tissue, and together with its associated proteins, forms the basis of intercellular substance.

Dermal fillers with hyaluronic acid in aesthetic medicine

The popularity of dermal fillers with hyaluronic acid is steadily increasing. In the recent past, they were timidly used to fill single wrinkles and lip augmentation, but today they are one of the main tools for non-surgical facelift and overall face modeling – cheekbones, chin, around the eyes, forehead, nose, etc., for corrections on the neck, décolletage, arms, for bumps, scars and asymmetries.

The modern pharmaceutical and cosmetic industries are developing at an extremely rapid pace. Companies producing dermal fillers with hyaluronic acid are constantly doing research and every year new developments of already existing products as well as completely new dermal fillers appear on the market.

In addition to restoring the skin’s normal hydrobalance, hyaluronic acid dermal fillers stimulate fibroblasts to produce their own collagen. Clinical experience has shown that follow-up treatments and adjustments with hyaluronic acid dermal fillers, mesotherapy and Botox along with the use of quality cosmetic products and photoprotector can preserve youthful and healthy looking skin for a long time and improve quality of life.

What is hyaluronic acid?

Hyaluronic acid is a natural product that is found in the body. It is a powerful tool for hydrating the skin and creating volume where there is tissue loss. Hyaluronic acid has the extraordinary ability to attract and retain water, weighing nearly a thousand times more than its own weight, and thus create volume and density, maintain the skin’s optimal hydro balance, increase its elasticity and slow down the aging process.

Stabilized hyaluronic acid, which is used in so-called injectable hyaluronic acid dermal fillers, is the most popular temporary and fully resorbable material that specialists have been using successfully for years for aesthetic non-surgical corrections related to soft tissue loss. Hyaluronic acid obtained by biotechnology is characterized by high purity and very good biocompatibility.

How do dermal fillers with hyaluronic acid differ?

Abstracting from the different formulas and technologies, which are closely guarded secrets of the manufacturers, dermal fillers differ mainly in the concentration and degree of crosslinking of hyaluronic acid in a unit of product. The principle is simple – the higher the concentration of hyaluronic acid and its degree of crosslinking, the firmer and more durable the final product.

Teoxane Redencity 1 texture

To fill superficial wrinkles, a low hyaluronic acid and/or low cross-linking dermal filter is used, which is more fluid, absorbs quickly and is also less durable.

While for chin contouring, for example, a product with a high hyaluronic acid content and/or a high degree of cross-linking is used, which is firmer, absorbs slowly and is very durable.

Teoxane Ultradeep texture

How long does it take to insert dermal fillers with hyaluronic acid?

The placement of dermal fillers with hyaluronic acid takes about 15-30 minutes. It is necessary to allow an additional 30 minutes for a consultation before the actual procedure.

Is it painful to have injected dermal fillers with hyaluronic acid?

The smooth consistency of hyaluronic acid dermal fillers allows for easy and smooth injection. Many products also contain a small percentage of lidocaine to reduce injection pain and for greater comfort. Additionally, a local anaesthetic in the form of a cream is applied.

When does the result of hyaluronic acid dermal fillers appear?

The effect of placing dermal fillers with hyaluronic acid is noticeable immediately after the procedure, with the final result developing over a period of up to 2 weeks.

Is there a recovery period after hyaluronic acid dermal fillers?

Absolutely not! Dermal fillers with hyaluronic acid can be applied during your lunch break and immediately afterwards you can continue your working day.

Are there any side effects of hyaluronic acid dermal fillers?

Immediately after the injection of hyaluronic acid dermal fillers, slight redness, swelling, or a bruise-like sensation may occur in the injection area. Your doctor can advise you on how to deal with this. These side effects do not last long and can be easily covered up with the make-up you use daily.

How long does the result of hyaluronic acid dermal fillers last?

The durability of the effects of hyaluronic acid dermal filler injections is individual to each person and is related to many factors such as: age, injection area and amount, skin quality, lifestyle and health, but is most commonly between 10 and 18 months.

How should I prepare for hyaluronic acid dermal fillers?

You are advised to avoid taking aspirin or other non-steroidal anti-inflammatory drugs prior to the injection of a hyaluronic acid dermal filler. This will reduce the risk of bleeding and hematoma formation in the injection areas.

How many treatments should I do to achieve the desired effect?

Re-injection of hyaluronic acid dermal filler is not necessary! Many patients desire refreshers as well as repeat treatments to maintain the result they have achieved.

Are there alternative dermal fillers that are not hyaluronic acid?

Dermal fillers are of two types – temporary or those that are absorbed by the body and their effect diminishes and disappears over time and permanent – those that are not absorbed by the body and their effect does not disappear. The latter, are banned for use in most of the world due to the numerous side effects of their use. The best known of these is liquid silicone, which has been widely used in the past.

Temporary or absorbable dermal fillers can be hyaluronic acid based or other active substances such as:

Calcium hydroxylapatite – Radiesse

Calcium hydroxylapatite occurs naturally in human bones and is a mineral-like compound. Radiesse is often used for: Moderate to severe folds, such as nasolabial folds, marionette lines, and wrinkles; Increasing the fullness of cheeks and other facial contours; Improving volume in areas of facial loss.

Calcium Hydroxyapatite is produced biosynthetically, meaning no animals or animal products are used. This reduces the risk of allergic reaction and no skin test is required. This type of dermal filler is known to give a very natural result, does not migrate and side effects are rare. This dermal filler was first used in dentistry and reconstructive surgery and has a long safety record.

Polylactic acid – Sculptra

Polylactic acid is a synthetic dermal filler that is injected into your face, triggering your body’s own production of collagen. This type of dermal filler is known as a stimulator. This non-toxic, biodegradable substance has been used for over 40 years as a suture material.

Polylactic acid is known to work especially well in the lower half of your face and is used to: Fill in laugh lines; Plump thin lips; Treat deep nasolabial folds.

This substance differs from other dermal fillers because it does not give immediate results. Instead, it stimulates the production of collagen in your own body, so the results appear gradually over several months. It takes several treatments – 3 or more each month to achieve the desired results. With each treatment, your own collagen is re-stimulated. It may then take four to six weeks to see the full effect. Although this type of dermal filler is considered semi-permanent, you may still need periodic adjustments.

Polymethylmethacrylate microspheres (PMMA) – Bellafill

PMMA is considered a semi-permanent dermal filler and is most commonly used to treat medium to deep wrinkles, folds and furrows, especially nasolabial folds. It can also be used to fill depressions from scars and to augment thin lips. One of the disadvantages of PMMA is that several injections are needed to create volume and it can take up to three months to achieve the full effect. It may also be visible under the skin.

The doctors-dermatologists at Skin Line Clinic Sofia and Varna are certified and trained to work with all dermal fillers with hyaluronic acid registered on the Bulgarian market.

Most commonly used dermal fillers with hyaluronic acid at Skin Line Aesthetic Clinics


JUVÉDERM™ Voluma™, Volbella™, Volift™ and Volux™ are the four newest JUVÉDERM™ hyaluronic fillers in the Vycross range


JUVÉDERM™ Ultra are hyaluronic products with a wide range of different densities to achieve a natural and long-lasting result

Teosyal Express Yourself Teosyal RHA2, RHA3


TEOSYAL RHA® - The world's first long-lasting hyaluronic fillers dedicated to facial dynamics.


Teosyal Multilayering combines two volumizing products: TEOSYAL® ULTRA DEEP and TEOSYAL RHA® 4

Elasty featured image

ELASTY - natural hyaluronic fillers

the best in its class thanks to the unique preserved natural crosslinking technology

Hyaluronic fillers Revolax

Revolax are a range of revolutionary fillers, innovative, guaranteeing excellent results and durability.

Other dermal fillers with hyaluronic acid

Prices of procedures with hyaluronic acid dermal fillers at Skin Line Aesthetic Clinics

Book a consultation in Skin Line Sofia Mladost

Sofia, Mladost 4, 91 Alexander Malinov blvd.

Book a consultation in Skin Line Sofia Center

Sofia, 12-16 Dragan Tsankov blvd.

Book а consultation in Skin Line Varna

Varna, 53 Kniaz Boris I blvd.
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