Signature White

Signature PRP & PRF

are regenerative therapies developed by Mihail Mihailov MD in Skin Line Aesthetic Clinics



Signature PRP (platelet rich plasma) and Signature PRF (fibrin rich plasma) therapies are completely natural and use the patient’s own blood plasma to improve the quality and appearance of the skin on the face and body. Because each patient is unique, Signature PRP and Signature PRF therapies combine the power of regenerative medicine and are carefully selected according to specific needs and whole active ingredients.

An innovation in our clinics is the additional enrichment of PRP plasma. To achieve a better effect, our specialists add cocktails of vitamins, minerals, amino acids, nucleic acids, coenzymes, trace elements, antioxidants, non-crosslinked hyaluronic acid and others. After an individual consultation with each patient, dermatologists decide what amount and type of enrichment will be needed. Plasma, rich in platelets, growth factors, micro- and macronutrients, affects the skin in two ways – on the one hand, growth factors awaken the skin stem cells to divide, and on the other hand through additional vitamins, minerals, amino acids and more. promotes the growth of these cells.


PRP Plasmotherapy

PRP (platelet-rich plasma) therapy, also known as “vampire lifting”, has become one of the most commonly used natural rejuvenation procedures in recent years. This is the only therapy in aesthetic medicine that uses the body’s natural resources.


PRF Plasmotherapy

Fibrin is a biological scaffold that forms when an injury occurs anywhere in the body. Platelets normally circulate in the blood and bind to the fibrin scaffold. Thus connected, they are activated and release growth factors, which are small “granules”. These growth factors begin the process of wound healing by creating new skin cells, collagen and blood vessels.


for every age

Signature PRP and Signature PRF therapies are suitable for all ages and skin types, and due to their completely natural origin are recommended for patients with allergies and sensitivity to other products. They can be combined with all other aesthetic and cosmetic procedures.


for face and body

Signature PRP and Signature PRF therapies are suitable not only for facial skin, but also for all areas of the body. In Skin Line we successfully apply PRP therapies for scalp and hands, neck and décolleté, as well as, for the first time in Bulgaria, P-Shot and O-shot – plasma therapy for the male and female intimate area, which treat age-related problems, as well as sexual dysfunction.

Book a consultation at Skin Line Plovdiv

Plovdiv, 91 Maritsa Blvd.

Book consultation in:

Book a consultation at Skin Line Sofia Mladost

Sofia, Mladost 4, Blvd. Aleksandar Malinov 91

Book a consultation at Skin Line Sofia Center

Sofia, 12-16 Dragan Tsankov Blvd.

Book a consultation at Skin Line Varna

Varna, 53 Knyaz Boris I Blvd.

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